- Amino acids directly function in metabolism so their levels are important biomarker for nutritional and health status.
- Amino acid analysis reflects unique profiles for different health conditions even years before diseases onset.
- Amino acid analysis has a prediction potential for future health risks such as insulin resistance, type 2 diabetes, cardiovascular diseases, obesity, depression and Alzheimer’s disease etc.
- Amino Acid Science Limited has already developed a utility model of amino acids reporting system which provides a smart and comprehensive interpretation for health assessment and nutritional status.
Why do you need amino acid analysis?
- Amino acid profiling of biological samples could be used to generate indices that could be used for clinical diagnosis and is a useful tool for understanding metabolic implications under various physiological conditions.
- Amino acids could be useful indicators for facilitating nutritional management of specific physiological and pathological states.
Current Opinion in Clinical Nutrition and Metabolic Care 2009, 12:49–53
(34th Annual International Conference of the IEEE EMBS San Diego, California USA, 28 August - 1 September, 2012)
Examples of Amino Acids as Biomarkers for metabolic diseases, neurodegenerative diseases and cancers:
- Metabolism. 2013 Jul;62(7):961-9. doi: 10.1016/j.metabol.2013.01.007.
Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness.
Batch BC, et al
- Pediatr Obes. 2013 Feb;8(1):52-61. doi: 10.1111/j.2047-6310.2012.00087.x.
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.
McCormack SE, et al
- Eur Heart J. 2013 Jul;34(26):1982-9. doi: 10.1093/eurheartj/ehs424.
A diabetes-predictive amino acid score and future cardiovascular disease.
Magnusson M,et al.
- PLoS One. 2011;6(9):e24143. doi: 10.1371/journal.pone.0024143.
Plasma free amino acid profiling of five types of cancer patients and its application for early detection.
Miyagi Y ,et al.
- PLoS One. 2016 Aug 4;11(8):e0160542. doi: 10.1371/journal.pone.0160542. eCollection 2016.
Branched-Chain Amino Acids as New Biomarkers of Major Depression - A Novel Neurobiology of Mood Disorder.
Baranyi A et al.
- Amino Acids. 2019 Mar;51(3):367-371. doi: 10.1007/s00726-019-02705-6.
Amino acid profiling as a method of discovering biomarkers for diagnosis of neurodegenerative diseases.
Socha E et al.